Week 7 study guide NR 566

Non-pharmaceutical treatment of symptoms associated with menopause
 Exercise, relaxation techniques, massage therapy, acupuncture, herbs
 Ginseng, black cohosh, licorice, carrots, yams, calcium, vitamin e and d, SOY
Pharmacokinetic gender differences between men and women
 Absorption and bioavailability
o Gastric emptying is slower r/t effects of estrogen
o Gastric levels of alcohol dehydrogenase are lower in females
 Distribution
o Females have lower body wts and BMI
o Females have higher proportion of body fat, lipophilic drugs more readily
absorbed
o Plasma volume is lower in females
o Organ blood flow is lower in females
 Metabolism
o Females have lower levels of p-glycoprotein and higher rates of drug clearance
for drugs that are substrates of p-glycoprotein
Rationale drug selection for PMDD
 1st- SSRIs- Fluoxetine, paroxetine, sertraline,
 2nd- Xanax, spironolactone
 Calcium, mag, tryptophan, vit b6, vit E
Treatment for primary dysmenorrhea
 NSAIDs 2-3 days before period
Recommended calcium and vitamin D intake for adolescents and adults
 1,000 50 and younger of, 1200 older than 50
LGBTQ population
 Increased rates in smoking, ETOH, depression, HIV/AIDS, violence and suicide rates
Chapter 49: Men as Patients
Testosterone therapy and monitoring
 Erythrocytosis- H/H need to be monitored
 If Hct > 54% tx is stopped
 Should also be evaluated for hypoxia and sleep apnea
 Risk or prostate CA
 Evaluate pt 3-6 months after tx is started
Contraindications for testosterone replacement therapy
 Abnormal digital rectal exam
 Breast CA
 Elevated PSA levels
 Hypercoagulable states
This